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Calpain-1 knockout reveals broad effects on erythrocyte deformability and physiology

It has been efficient in increasing the TDDs with varying molecular weights including small (fentanyl, orcalcein) to high molecular weight drugs weighing up to 40 kDa

Virtually all cells in the body contain an abundance of glutathione, known as the bodys master antioxidant. Glutathione is involved in essential cellular functions, including protecting the cell from oxidative stress, and is vital to overall health and wellness. When glutathione levels are suboptimal or deficient, it affects health throughout the body, resulting in symptoms and increased risk for chronic diseases

The resulting IC 50 values summarized in Table 1 were used to orient our experiments and give the reader an impression of the pharmacological range in which the experiments took place

Glutathione is not merely a passive shield